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Therefore, the pro-apoptotic effect of tamoxifen is partially dependent on the inhibition of FLIP expression and inhibition of pAkt and stimulation of caspase activity in vivo and in vitro, respectively [87]

doi:10.1016/S1262-3636(17)30067-8 23

Glucose and glutamine as energetic substrates are considered a hallmark of cancer cells and the metabolic switch that allow their utilization under virtually anaerobic conditions is known as the Warburg effect (Warburg et al., 1927)